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KMID : 1100220100090040136
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Dementia and Neurocognitive Disorders
2010 Volume.9 No. 4 p.136 ~ p.139
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Insulin Resistance and Cognitive Impairment in Non-Diabetic Patients
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Park Hyung-Jong
Park Do-Sim
Park Hyun-Young
Chang Hyuk
Kim Yo-Sik
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Abstract
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Background: Type 2 diabetes mellitus (DM2) is associated with cognitive impairment. Peripheralinsulin resistance is known to be the major contributor to the progression of hyperglycemiaand DM. However, the relationship between insulin resistance (IR) and the risk of cognitivedecline in non-diabetic patients is not clear so far.
Methods: We analyzed 18 Alzheimer disease(AD) patients, 19 mild cognitive impairment (MCI) patients, and 24 cognitively healthycontrols without diabetes. We examined their demographic characteristics, current and pastillness and Mini-Mental State Examination (MMSE). We also examined insulin resistance index(Homeostasis Model Assessment of Insulin Resistance, HOMA-IR) as an indicator of IR and afactor associated with cognitive decline.
Results: Levels of HOMA-IR were significantly differentamong the 3 groups (p<0.05) and HOMA-IR levels detected in the AD group were higherthan those in the MCI and control groups. They were negatively correlated with the MMSE(p<0.01) and significantly connected with the cognitive decline subjects (r=-0.351, p<0.01).Multiple regression analysis revealed that the level of HOMA-IR was independently associatedwith cognitive decline (p<0.05).
Conclusions: HOMA-IR levels were related to cognitivedecline and these results suggest that HOMA-IR may be an important risk factor of dementia.
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KEYWORD
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Insulin resistance, Dementia, Risk factor
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